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The UN agency for Palestinian refugees warned Thursday it has reached a critical juncture as it struggles to cope with the war in Gaza.

"It is with profound regret that I must now inform you that UNRWA has reached a breaking point," chief Philippe Lazzarini said, as donors freeze funding, Israel exerts pressure to dismantle the agency and humanitarian needs soar.

"The Agency's ability to fulfill the mandate given through General Assembly resolution 302 is now seriously threatened," he said in a letter to the assembly.

That is the resolution under which the agency was founded in 1949, following the creation of Israel.

UNRWA employs some 30,000 people working in the occupied territories, Lebanon, Jordan and Syria.

Several countries - including the United States, Britain, Germany and Japan - have suspended funding to UNRWA in response to Israeli allegations that some of its staff participated in Hamas' October 7 attack on Israel.

In an interview published over the weekend Lazzarini said $438 million has been frozen - the equivalent of more than half of expected funding for 2024. He said Israel was waging a concerted effort to destroy UNRWA.

The UN fired the employees accused by Israel and has begun an internal probe of UNRWA.

UN Secretary-General Antonio Guterres has also tasked an independent panel with assessing whether UNRWA acts in a neutral fashion in the Israeli-Palestinian crisis.

Lazzarini asserted Thursday that Israel has provided no evidence against the 12 former employees it accuses, but 16 countries have suspended funding anyway.

Analysis: Israeli accusations against UNRWA are part of a long-running interest in disbanding the UN agency and nullifying the issue of Palestinian refugees

The end of UNRWA? Why Israel is targeting the Palestinian refugee agency ⬇️

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"I have cautioned donors and host countries that without new funding, UNRWA operations across the region will be severely compromised from March," he said.

He added: "I fear we are on the edge of a monumental disaster with grave implications for regional peace, security and human rights."

Israel's latest war on Gaza ignited after the unprecedented October 7 attack which resulted in the deaths of about 1,160 people in Israel, according to Israeli figures. Hamas also took about 250 hostages - 130 of whom remain in Gaza, including 30 presumed dead, according to Israel.

Hamas says the attack came in response to decades of Israel's blockade of Gaza and aggression against the Palestinians.

Israel's air and ground offensive has since killed at least 29,410 people, mostly women and children, according to the latest count by Gaza's health ministry. Much of the enclave has been reduced to rubble.