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Idlib has witnessed another bloody day of bombing.
Turkey, Russia and Iran will meet in August to discuss the situation in Syria.
Hundreds have been killed and almost 400,000 displaced since late April, when the Syrian regime and its Russian ally began a deadly campaign to recapture the anti-regime bastion.
Hundreds of civilians have been killed and thousands of homes destroyed in a three-week regime offensive against Eastern Ghouta.
Eight members of an Al-Qaeda-linked rebel group, including six commanders, were killed in a missile attack in Syria's rebel and jihadist-held northwest, a war monitor said.
At least 72 people, including nine children, were killed in an airstrike that released "toxic gas" on the rebel-held Syrian town of Khan Sheikhun on Tuesday, a monitor said.
A hospital in northwestern Syria where doctors were treating victims of a suspected chemical attack that killed more than 70 people on Tuesday has been bombarded.
The UN cannot guarantee that hospitals in rebel-held Idlib, which have shared their coordinates under a UN deconfliction system, will be protected from Russian and regime airstrikes.
UN mediator Staffan de Mistura has urged Russia, Iran and Turkey to help restore a ceasefire in Syria, warning that escalating violence was threatening peace talks in Geneva.
War planes from the Syrian or Russian air forces have hit a huge IS convoy in central Syria over the weekend, killing dozens of extremist fighters.