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Assad's fall will have far-reaching consequences for the region, especially those in the 'Axis of Resistance', including the Houthi movement.
The Syrian Arab Army is no more, an institution built to fight Israel that eventually ate itself due to rampant corruption and ineptitude.
Syria's Bashar Al-Assad faces a difficult tightrope walk as allies in the region, such as Hassan Nasrallah, are taken out by Israel in quick succession.
The Houthis could seek to bolster their status after Nasrallah's killing, having already played an oversized regional role since Israel's war on Gaza began.
Syria has witnessed another year of extreme suffering in 2022, with the next 12 months expected to get worse for other reasons. We spell out the three key issues that will affect Syrians in 2023.
Movements in the US Congress could see action against the Assad regime's captagon trade, but after years of negligence could it be too late?
Lebanon and Iraq have agreed to cooperate with Israel on climate change issues at COP27 despite there being no diplomatic relations and a continuing state of hostility.
Shia cleric Muqtada al-Sadr has continued to forge ahead with his ambitions of being the power behind Iraq's major political institutions, sowing chaos in the country until his demands are met.
The political instability that has wrangled Iraq since October's elections has spilled over into the Gulf, as Iran-backed Iraqi and Yemeni groups target the UAE.
Whilst the main protagonists of the Iran-Iraq War have long departed, the seeds sowed by the conflict continue to have rippling effects for the region today. With Iranian soft power at unprecedented levels, what will the future hold for Iraq?