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An Israeli air raid has reportedly targeted the Mediterranean port town of Latakia, ancestral home of President Bashar al-Assad, leaving one civilian dead and six wounded.
The Russian flight appears to be the first of its kind connecting Israel's Ben Gurion airport with Syria's Latakia governate, a regime stronghold.
A new shipping line has been established between the Syrian port of Latakia and the Iranian port of Bandar Abbas, in an effort to stimulate trade between Syria and Iran.
Hundreds of hectares had burned in the countryside of Syria's coastal Latakia and Tartus provinces, and in the central Homs province.
Russia has been given approval to expand its airbase in Latakia province.
The town, a gateway to the strategic government-held town of Saraqeb, lies on the M4 highway, connecting the port city of Latakia to the Iraqi border.
General Igor Konachenkov told journalists on Friday that 58 drones and 27 missiles were intercepted by Russian forces at the base in the coastal province of Latakia.
Fighting in southern Idlib and rural Latakia on Tuesday claimed the lives of 29 pro-government forces as well as 30 jihadists and allied rebels.
Syria's former Al-Qaeda affiliate Hayat Tahrir al-Sham (HTS) controls most of Idlib province as well as parts of neighbouring Aleppo, Hama and Latakia provinces.
A Russian aircraft has gone missing off Latakia coast, following a series of Israeli air raids in Syria.