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Turkey's president has accused Syria of attempting to derail cooperation between Ankara and Moscow following the regime's latest offensive.
The head of Syria's former Al-Qaeda affiliate released a video urging supporters to "take up weapons" to defend Idlib.
UN-linked aid groups have suspended activities in parts of violence-plagued northwest Syria, where stepped up bombardment by the regime and Russia is jeopardising the safety of humanitarian workers.
The chief of the UN's Syria commission warned of a possible humanitarian disaster if fighting over Idlib is to continue.
United Nations Secretary-General Antonio Guterres urged the warring parties in Syria's northwest to protect civilians and respect a ceasefire.
Russia and Syrian regime forces intensified shelling in the rebel-held northwestern province of Idlib overnight on Wednesday, local medics and activists reported.
A Syrian rebel force has said that they have killed four Russian soldiers in the country's north as the regime and Moscow have stepped up their bombardment of the area.
Hayat Tahir al-Sham, or HTS, said the attacks were in retaliation for the bombardment by the Syrian and Russian militaries of rebel-held area in recent days.
At least 12 people have been killed and dozens of others have been injured in an explosion in the rebel-held city of Jisr al-Shughour in northern Idlib province in Syria.
The Islamic State group has stepped up its attacks in Syria following the loss of the last 'caliphate' territory, killing 69 regime-linked fighters over the past month.