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An airstrike killed eight family members, five of them children, as they fled fighting between US-allied Syrian forces and Islamic State militants on Monday, according to local activists, who said the strike appeared to have been launched by the US-led coalition.

The family was fleeing fighting in the northern Syrian town of Tabqa when their vehicle was struck, according to the Britain-based Syrian Observatory for Human Rights, which said the five children were between six months and 15 years old.