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Hamas on Sunday urged Gaza mediators to implement a truce plan presented by US President Joe Biden instead of holding more talks, as Palestinians fled new Israeli military attacks.

The statement from the Palestinian group came a day after one of the deadliest strikes on civilians in the besieged Gaza Strip in more than 10 months of war.

International mediators had invited Israel and Hamas to resume talks towards a long-sought truce and hostage-release deal, after the fighting in Gaza and the killings of Iran-aligned militant leaders sent tensions soaring across the region.

Israel, whose Prime Minister Benjamin Netanyahu has been accused of prolonging the war for political gain, has accepted the invitation from the United States, Qatar and Egypt for a round of talks planned for Thursday.

Hamas said Sunday it wanted the implementation of a truce plan laid out by Biden on May 31 and later endorsed by the UN Security Council, "rather than going through more negotiation rounds or new proposals".

Hamas "demands that the mediators present a plan to implement what they proposed to the movement... based on Biden's vision and the UN Security Council resolution, and compel the (Israeli) occupation to comply", it said.

Unveiling the plan, Biden had called it a three-phase "roadmap to an enduring ceasefire and the release of all hostages", and said it was an Israeli proposal. Mediation efforts since then have failed to produce an agreement.

Hamas on Tuesday named its Gaza chief Yahya Sinwar to succeed slain political leader and truce negotiator Ismail Haniyeh, killed last week in Tehran in an attack blamed on Israel, which has not claimed responsibility.

Haniyeh's killing, just hours after Israel assassinated the military chief of Lebanon's Hezbollah in a strike on Beirut, spurred fears of a wider war in the Middle East and intense diplomacy to avert it.

In Khan Yunis, southern Gaza's main city already ravaged by months of Israeli bombardment and attacks, AFP journalists said hundreds of Palestinians had fled northern neighbourhoods after Israel issued fresh evacuation orders.

The Israeli military dropped leaflets and sent mobile phone messages warning of "dangerous combat" in Al-Jalaa district and telling Palestinian residents to leave the area, which until Sunday had been designated a "humanitarian safe zone".

Similar evacuation orders have preceded major military incursions, often forcing Palestinians displaced numerous times by the war to pack up and leave for safety.

Massacre

The military said in a statement its forces were "about to operate against the terrorist organisations in the area", calling on "the remaining population left in the Al-Jalaa neighbourhood to temporarily evacuate".

It came a day after civil defence rescuers said an Israeli air strike killed 93 people at a religious school housing displaced Palestinians, sparking international condemnation.

Mahmud Bassal, spokesman for the civil defence agency, said on Sunday that identifying the victims could take at least two days as "we have many bodies torn into pieces" and "shredded or burnt by the bombs".

Hamas in its Sunday statement cited the Israeli "massacre against the displaced at Al-Tabieen school" and "our responsibilities towards our people and their interests" as the reasons for its announcement.

The Gaza war began after a Hamas-led surprise attack on Israel on October 7 which resulted in the deaths of 1,198 people.

Palestinian fighters also seized 251 people, 111 of whom are still held captive in Gaza, including 39 the Israeli military says are dead.

Israel's indiscriminate military offensive against Gaza has killed at least 39,790 people, the vast majority of them civilians.

Biden said the first phase of the proposed roadmap includes a "full and complete ceasefire" lasting six weeks, with Israeli forces withdrawing from "all populated areas of Gaza" and some hostages freed in exchange for Palestinian prisoners held by Israel.

The second phase would see the remaining living hostages released as the warring sides negotiate "a permanent end to hostilities", followed by "a major reconstruction plan for Gaza" and the return of dead hostages' remains.

'Where to go?'

German Chancellor Olaf Scholz told Netanyahu in a phone call on Sunday that "an end to the war in Gaza would be a decisive step towards a regional de-escalation".

Many analysts and observers have said Netanyahu has sought to prolong the fighting for political gain.

Tensions soared as Iran, Hamas, Hezbollah and other regional allies have vowed retaliation for Haniyeh's killing and that of Hezbollah's military chief Fuad Shukr.

Biden, asked what his message was to Iran, responded: "Don't."

The UN agency for Palestinian refugees, UNRWA, said that "just in the past few days, more than 75,000 people have been displaced in southwest Gaza", where Khan Yunis is located.

The entire Gaza Strip has a population of about 2.4 million people.

Umm Sami Shahada, a 55-year-old displaced Palestinian, said she had "fled Gaza City at the start of the war for Khan Yunis", hoping to find shelter.

"My daughter was killed in bombardment, so we went to Rafah, then we came back here, and now with this new evacuation order we don't know where to go," she said.

Families gathered their meagre belongings as crowds of people left Al-Jalaa, some loading mattresses, clothing and cooking utensils into pick-up trucks. Others took to the road on foot or left on donkey-drawn carts.

Majd Ayyad, displaced from Gaza City, said: "We have to go somewhere, and we don't know if it will be good or bad."