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Turkish President Recep Tayyip Erdogan has said that the Islamic State group was the "likely perpetrator" of a bomb attack that killed at least 50 people at a wedding celebration in Gaziantep, close to the Syrian border.

The death toll of Saturday's bombing has risen to 50, in one of the bloodiest attacks by IS in Turkey.

The explosion - reportedly triggered by a suicide bomber - was the latest attack to rock the key NATO member in a horrific year that has seen strikes blamed on Kurdish and IS militants, coinciding with dozens dead from July's botched coup attempt.

Erdogan said in a statement there was "no difference" between the group of US-based preacher Fethullah Gulen who he blames for the failed coup bid, the outlawed Kurdistan Workers Party (PKK) "and Daesh (IS), the likely perpetrator of the attack in Gaziantep".

"Our country and our nation have again only one message to those who attack us - you will not succeed!" he said.

Kurds Targetted

Reports suggest that the wedding crowd was mostly Kurdish. The Dogan news agency said the bride and groom were from the mainly Kurdish region of Siirt further to the east and had themselves been uprooted due to the flare-up in violence with Kurdish militants.

The pro-Kurdish Peoples' Democratic Party (HDP) said its members had been present at the wedding which was also attended by many women and children.

The Hurriyet daily said the bride and groom - Besna and Nurettin Akdogan - were in hospital but their lives were not in danger.

Erdogan said the aim of such attacks was to sow division between different groups in Turkey such as Arabs, Kurds and Turkmen and to "spread incitement along ethnic and religious lines".

Many militants see Kurds as one of their main enemies, with Kurdish militias playing a significant role in the fight against IS on the ground in Syria.

Prime Minister Binali Yildirim said Gaziantep would show the same spirit it had shown in 1921 when it defeated French forces in Turkey's Independence War which led to the word Gazi (war hero) being added to its original name of Antep.

"Our grief is great but be sure our unity and togetherness will defeat all these diabolic attacks," he said.

'Happiest day poisoned'

Mehmet Erdogan, a ruling Justice and Development Party (AKP) lawmaker for Gaziantep said there was a "high possibility" it was a suicide attack, comments echoed by Deputy Prime Minister Mehmet Simsek.

Dogan news agency said the suicide bomber had mixed in with the guests before detonating the charge. Security forces are now searching for two individuals who entered the celebration with the suspected bomber and then fled, it added.

Gulser Ates, who was wounded in the attack, told Hurriyet the attack took place as the party was breaking up.

"We were sitting on chairs, having a chat with one of our neighbours.

"During the explosion, the neighbour died on top of me. I remember being underneath. If my neighbour hadn't fallen on top of me, I would have died," she said.

"The bride and groom's happiest day was poisoned."

Hub for Syrians

A major city lying just 60 kilometres (37 miles) north of the Syrian border, Gaziantep has become a hub for Syrians fleeing the civil war in their country and anti-IS and regime activists who have been targeted by the militants.

But as well as refugees and opposition activists, there have long been fears it was home to a significant militants presence.

Images from the scene showed bodies covered in white sheets while distraught relatives of the victims were comforted in the street.

Police also fired in the air to prevent further tensions after scuffles broke out when a group brandishing Turkish flags arrived on the scene, images showed.

As has been the case in previous attacks, Turkey's broadcasting regulator RTUK banned broadcast of footage from the scene of the attack in Gaziantep.

IS suicide bombers have carried out attacks in Istanbul several times this year, while Kurdish militants have hit targets in both Ankara and Istanbul.

On Thursday, 12 people were killed in a spate of bombings blamed on the PKK, who Erdogan said had killed 70 members of the security forces in the last month alone.

The blast in Gaziantep came just hours after Yildirim said Ankara would in the next six months play a "more active" role in efforts to solve the Syrian civil war.

Turkey was long accused of turning a blind eye to or even abetting the rise of IS in Syria, claims it vehemently denies, but has taken a tougher line after the militant attacks on its soil.