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Dr Hasan al-Araj was Hama's only surviving heart specialist. His car was 'targeted' by aircraft operating over the hospital in the rebel-held territory.
Syrian opposition forces recaptured two villages in the Hama countryside, west-central Syria, on Friday, amid reports of heavy regime casualties.
Hundreds of thousands of more Syrians have been displaced by fighting since the beginning of October, as the conflict morphs into a multi-sided civil war with various different actors.
Rebels claim that at least one Russian helicopter was downed in Hama province on Thursday where a major Syrian regime offensive is underway.
Opposition fighters claim to have fought off the first wave of a major regime assault by government troops bolstered by Russian air raids and cruise missiles from warships.
A notorious Syrian army commander known is set to head a military offensive to capture opposition-held territory in northern Hama.
Syrian rebels continued their advance towards Homs after capturing the key city of Hama, while seizing border crossings with Jordan in the south of the country
Defections and poverty are threatening the Syrian military, faced with a sweeping rebel offensive which captured Hama on Thursday.
Iraq's Iran-backed factions prepare to deploy to Syria as Baghdad pledges support to Assad amid regime losses in Aleppo, Idlib, and Hama.
Syria's new authorities have arrested nearly 300 individuals, including informants, pro-regime fighters, and former soldiers.