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The US said they are "not trying to get rid of Assad," but would not send aid.
UN representatives have repeatedly warned about the threat of famine faced by Gaza's 2.3 million residents, the majority of whom are displaced.
The US passes a $900 billion Covid-19 relief bill, which includes hundreds of millions of dollars in aid to Israel, prompting national outrage.
The US decision to suspend funding to UNRWA has come under scathing criticism by aid organisations, who note that the ICJ ordered an increase of aid into Gaza.
US National Security Spokesman John Kirby said the talks in Doha began with a 'promising start' and will continue on Friday.
US Defense Secretary Lloyd Austin praised Cairo's role as "a responsible stabilising force" in the Middle East, according to Egypt's presidential spokesman, sparking outrage among activists.
It comes as Itamar Ben-Gvir attempts to place the Israeli police further under his control, with the police commissioner becoming subordinate to Gvir's office.
Despite Gaza's civilian death toll rising exponentially, the US has ruled out withholding arms from Tel Aviv.
Israel said it would end a humanitarian aid programme for Syria dubbed "Operation Good Neighbour".
The Jordan-hosted summit seeks to 'determine means for enhancing' the international community's response to the dire humanitarian situation in Gaza.