Syria's army command notified officers on Sunday that President Bashar al-Assad's 24-year authoritarian rule has ended, a Syrian officer who was informed of the move told Reuters, following a rapid rebel offensive that took the world by surprise.
Following are reactions from around the world to events in Syria:
United States
"President Biden and his team are closely monitoring the extraordinary events in Syria and staying in constant touch with regional partners," the White House said in a statement.
"The United States will continue to maintain its presence in eastern Syria and will take measures necessary to prevent a resurgence of the Islamic State," Deputy Assistant Secretary of Defense for the Middle East Daniel Shapiro told the Manama Dialogue security conference in Bahrain.
Shapiro called on all parties to protect civilians, particularly minorities, and respect international norms.
US President-elect Donald Trump said: "Assad is gone. He has fled his country. His protector, Russia, Russia, Russia, led by Vladimir Putin, was not interested in protecting him any longer," Trump posted on Truth Social. "Russia and Iran are in a weakened state right now, one because of Ukraine and a bad economy, the other because of Israel and its fighting success."
Italy
"I am following with concerned attention the evolution of the situation in Syria. I am in constant contact with our embassy in Damascus and with the office of the Prime Minister. I have called an emergency meeting at 10:30 at the Foreign Ministry", Tajani said on X.
United Nations
Special Envoy for Syria Geir Pedersen underscores the clear desire expressed by millions of Syrians that stable and inclusive transitional arrangements are put in place, a statement said.
He urged all Syrians to prioritize dialogue, unity, and respect for international humanitarian law and human rights as they seek to rebuild their society, adding he stands ready to support the Syrian people in their journey toward a stable and inclusive future.
"Today marks a watershed moment in Syria’s history - a nation that has endured nearly 14 years of relentless suffering and unspeakable loss... This dark chapter has left deep scars, but today we look forward with cautious hope to the opening of a new one—one of peace, reconciliation, dignity, and inclusion for all Syrians."
"Events in Syria moving at remarkable pace. More than decade of conflict has displaced millions. Now many more are in danger.
We will respond wherever, whenever, however we can to support people in need, including reception centres – food, water, fuel, tents, blankets", UN aid chief Tom Fletcher said.
Britain
"Dictatorship and terrorism creates problems for the people of Syria who have faced so much already and also destabilises the region. That's why we have to have a political solution where the government is acting in the interests of the Syrian people. That's what we want to see."
"That's the type of democracy that we say is right for the world, and that, hopefully, is what the Syrian people will get.
"If Assad has gone, that's a welcome change, but what comes next has to be a political solution, and they have to be working in the interests of the Syrian people."
The Philippines
The Philippines calls on all concerned parties to exercise restraint and refrain from further violence, to avert further casualties and deaths of civilians.
We express concern regarding the situation of our Filipinos in Syria and advise them to take the necessary precautions and stay in contact with the Philippine Embassy in Damascus.
Turkey
Syria has reached a stage where the Syrian people will shape the future of their own country, today there is hope, Turkish foreign minister Hakan Fidan said in a press conference in Doha.
The Syrian people cannot do this alone. Turkey attaches importance to Syrian territorial integrity. A new Syrian administration must be established inclusively, there should be no desire for revenge. Turkey calls on all actors to act with prudence and to be watchful. Terrorist organisations must not be allowed to take advantage of this situation. Opposition groups must be united. We will work for stability and safety in Syria.
The new Syria should not pose a threat to neighbours, it should eliminate threats. Any extension of the outlawed PKK militia cannot be considered a legitimate counterpart in Syria.
Russia
Syrians will have to cope with a full-scale civil war alone, deputy chairman of Russia's upper house of parliament Konstantin Kosachyov said, the Interfax news agency reported.
Germany
German foreign minister Annalena Baerbock said: "It is impossible to say exactly what is happening in Syria now. But one thing is clear: for millions of people in Syria, the end of Assad means the first big sigh of relief after an eternity of atrocities committed by the Assad regime."
"Assad has murdered, tortured and used poison gas against his own people. He must finally be held accountable for this.
"The country must not now fall into the hands of other radicals - regardless of the guise. We therefore call on the parties to the conflict to live up to their responsibility for all Syrians. This includes the comprehensive protection of ethnic and religious minorities such as Kurds, Alawites or Christians and an inclusive political process that creates a balance between the groups."
Italy
"I am following with concerned attention the evolution of the situation in Syria. I am in constant contact with our embassy in Damascus and with the office of the Prime Minister. I have called an emergency meeting at 10:30 at the Foreign Ministry", Italian foreign minister Antonio Tajani said on X.
Spain
"The situation appears to be peaceful. Spain has always hoped for a peaceful solution for Syria," foreign minister Jose Manuel Albares said.
France
France on Sunday welcomed news of the fall of Syrian President Bashar al-Assad and called for fighting to end and a peaceful political transition in the country.
"Now is the time for unity in Syria," the foreign ministry said in a statement.