The WHO warned Thursday of dire shortages of medicines, food, shelter and fuel in Gaza, especially in the north, demanding that Israel allow in more aid and facilitate humanitarian operations.
The World Health Organization described a "catastrophic" situation on the ground.
WHO chief Tedros Adhanom Ghebreyesus said that when the war in Gaza erupted more than a year ago almost all of those displaced by the conflict sheltered in public buildings or with family members.
"Now, 90 percent are living in tents," he told a press conference at the WHO's headquarters in Geneva.
"This leaves them vulnerable to respiratory and other diseases, (while) cold weather, rain and flooding are expected to exacerbate food insecurity and malnutrition," he said.
The situation was particularly dire in the north, where Israel has imposed an intensified siege and carried out deadly airstrikes.
A UN-backed assessment this month said famine looms.
Israel is believed to be carrying out a "General's Plan" in northern Gaza, with the intention of killing, starving, or expelling the remaining inhabitants.
The WHO and its partners this week conducted a three-day mission to the north, visiting more than a dozen health facilities.
Tedros said the team had seen "high number of trauma patients and increasing number of patients with chronic diseases needing treatment".
"There are critical shortages of essential medicines."
The WHO is "doing everything we can - everything Israel allows us to do - to deliver health services and supplies", he added.
Out of 22 requested missions to the north in November, only nine had been facilitated, Rik Peeperkorn, the WTO representative in the Palestinian territories, told reporters.
He said he hoped a planned mission on Saturday would go ahead to the only two remaining even "minimal" functioning hospitals in the north: Kamal Adwan and Al Awda.
"They are in need for everything," Peeperkorn said.
He described a dire lack of fuel especially, warning that "without fuel there are no humanitarian operations at all".
On a positive note, Peeperkorn said the WHO had facilitated this week the medical evacuation of 17 patients from Gaza to Jordan, 12 of whom would go on to the United States for treatment.
They were among nearly 300 patients who had been able to leave since Israel shuttered Gaza's main Rafah border crossing in early May, Peeperkorn said.
But around 12,000 patients are currently waiting in Gaza to be evacuated for medical reasons, he said, demanding medical corridors out of the territory.
"If we continue at this pace, we will be busy for the next 10 years," he said.