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UK nurses on Thursday staged an unprecedented one-day strike as a "last resort" in their fight for better wages and working conditions, despite warnings it could put patients at risk.

Up to 100,000 members of the Royal College of Nursing (RCN) in England, Wales and Northern Ireland are stopping work from 0800 to 2000 GMT after rejecting a government pay offer.

The RCN's industrial action is part of a growing wave of stoppages by public and private sector employees.

‘We strike for the future of the NHS.’

The largest strike in RCN history starts today, as nursing staff in England, Northern Ireland and Wales demand fair pay and patient safety.

— The RCN (@theRCN)

Picket lines were being set up at major state-run hospitals, including Guy's and St Thomas NHS Foundation Trust in London.

Ameera, a senior nurse in London, told AFP that "we have not chosen industrial action lightly".

The strike is the first in the Royal College of Nursing union's 106-year history.

"We're tired. We're fed up," added the nurse, who asked that her last name not be reported. "We need a pay rise now to make a living."

The UK is currently grappling with a cost-of-living crisis as spiralling inflation outstrips wage growth.

A message from that every nurse and member of the public needs to watch before tomorrow.

— NursingNotes (@NursingNotesUK)

Union leaders and health workers also said nurses were being overworked due to staff shortages, as the state-run National Health Service (NHS) battled a backlog in appointments made worse by cancellations during the pandemic.

Chemotherapy, dialysis, intensive care and high-dependency units, as well as neonatal and paediatric intensive care will be protected.

But other services will be reduced to Christmas staffing levels during the walk-out, the RCN said.

Saffron Cordery, interim chief executive of NHS Providers, said NHS trusts were "pulling out all the stops" to lessen the impact on patients.

"The picture will vary across the country as trust leaders work out service levels with unions locally," she added.

We stand with UK nurses today

— Marillion (@MarillionOnline)

Health chiefs warned unions that care levels could suffer because of the walkout, just as seasonal respiratory conditions such as flu add pressure on already stretched services.

Cally Palmer, national cancer director for England, called on the union to exempt cancer surgery from the walkout, while England's chief nursing officer expressed concern over the strike staffing plans.

"We hear from our colleagues that they are concerned by the assumption, implied by the RCN, that night duty staffing on day duty is safe," Ruth May wrote in a letter to the RCN.

"Ward activities during the day are very different to those at night.

"This decision has the potential to significantly impact on the safety of patient care (for example, by impacting delivery of intravenous antibiotics on time, patient observations and medication rounds)," she added.

Healthcare unions say their members are skipping meals, struggling to feed and clothe their families, and leaving the NHS in droves.

The RCN wants a pay rise significantly above inflation which surged to a 41-year high of 11.1 percent in October, falling slightly to 10.7 percent last month.

The government maintains the demands are unaffordable and Health Secretary Steve Barclay called the strikes "deeply regrettable".

RCN general secretary Pat Cullen has offered to "press pause" on the strikes if Barclay agreed to talks.

But Barclay insisted that while he was open to talks on wider issues, the pay settlement was recommended by an independent review body and would not be reopened.

The NHS Pay Review Body recommended a pay rise of at least £1,400 ($1,740) on top of a 3.0 percent pay rise last year, he said.

"Further pay increases would mean taking money away from frontline services at a time when we are tackling record waiting lists as a result of the pandemic," he added.

The main opposition Labour party leader Keir Starmer called the strike a "badge of shame" for the ruling Conservative government.

Accident and emergency staff nurse Mark Boothroyd, 37, said the cost-of-living crisis had left nurses struggling to pay bills, transport and rent.

Poor pay meant newly qualified nurses now spend only a year or two before leaving the profession, said Boothroyd, who works at St Thomas' Hospital in central London.

The resulting unfilled vacancies have put huge pressure on remaining staff, many of whom were reporting mental health problems from stress.

Conditions were "horrendous and cannot be allowed to go on", he added.