reaffirmed its call Tuesday for the Syrian opposition to "reconcile" with but stressed this did not represent a shift in Ankara's position on the war.
Foreign Minister comments came days after thousands of Syrians in rebel-held northern areas came out to protest Turkey's push for talks with Assad.
Turkey has opposed Assad throughout the 11-year conflict and backed some rebel groups in the war. However, Turkish forces have routinely targeted Kurdish forces, whom it considers 'terrorists', in northern Syria.
But Cavusoglu revealed last week that he had briefly met his Syrian regime counterpart Faisal al-Meqdad in Belgrade last October - the first such meeting reported since 2011.
"The regime and opposition need to reconcile," Cavusoglu told reporters Tuesday.
"The opposition trusts Turkey. We have never let it down. But we have always said that reconciliation is essential for permanent stability and peace in Syria."
Cavusoglu stressed that his push for talks reflected the "roadmap for peace" unanimously adopted by the UN Security Council in 2015.
Cavusoglu's comments had been seen as an apparent easing of Ankara's long-standing hostility towards Assad's government and enraged the Syrian opposition and rebel groups.
Syrians took to the streets after Friday prayers in major northern cities that remain under the control of Ankara's forces and their Syrian supporters near the Turkish border.
Turkey's interior minister said on Saturday that security officials had detained two people accused of burning the Turkish flag.