At least 21 Palestinians were killed in an Israeli attack on the al-Mawasi area in southern Gaza’s Khan Younis, confirmed civil defence spokespeople to Al Jazeera.
The Israeli air force launched two consecutive strikes, causing multiple makeshift tents to catch fire.
Emergency teams are working to control the blaze while conducting life-saving efforts.
This comes after another Israeli strike killed at least five people, including four children, earlier today.
The Awda Hospital, which received the bodies, said the five were gathered outside of shelters in the built-up Nuseirat refugee camp in central Gaza.
The hospital said another 15 people, mostly children, were wounded in the strike. There was no immediate comment from the Israeli military.
In Lebanon, a tenuous ceasefire between Israel and Hezbollah has held despite Israeli forces carrying out several new drone and artillery strikes on Tuesday, killing a shepherd in the country's south.
Israeli Prime Minister Benjamin Netanyahu vowed keep striking "with an iron fist" against perceived Hezbollah violations of the ceasefire.