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An Israeli air strike at a medical clinic in Gaza City killed the director of Gaza's Ambulance and Emergency Department, the enclave's health ministry said, while Israel's military claimed the strike had killed a senior Hamas armed commander.

The health ministry said the killing of Hani al-Jaafarawi brought the number of medical staff killed by Israel since 7 October to 500. At least 300 others have so far been detained.

In a statement, the Israeli military said the strike targeted Mohammad Salah, who it claimed was responsible for developing Hamas weaponry.

"Salah was part of a project to develop strategic weaponry for the Hamas terrorist organisation, and he commanded a number of Hamas terrorist squads that worked on developing weapons," it said.

More than eight months into the fighting, international mediation backed by the United States has so far failed to bring a ceasefire agreement. Israel says it will agree only temporary pauses in fighting until Hamas is eradicated, while Hamas says any agreement must bring a permanent end to the war, which US President Joe Biden's proposal included.

In Rafah, near the border with Egypt, Israeli forces which took control of the eastern, southern, and central parts of the city pursued their raid into the western and northern areas, said residents, describing heavy fighting.

On Sunday, residents had said Israeli tanks had advanced to the edge of the Mawasi displaced persons' camp in the northwest of Rafah, forcing many families to leave northward to Khan Younis and to Deir Al-Balah in central Gaza, the only city in the enclave where tanks have not yet invaded.

"The situation in Tel Al-Sultan, in western Rafah, remains very dangerous. Drones and Israeli snipers are hunting people who try to check on their houses, and tanks continue to take over areas overseeing Al-Mawasi further west," said Bassam, a resident of Rafah.

"We know about people killed in the streets and we know and we see that dozens of houses had been destroyed by the occupation," he told Reuters via a chat app.

In the north of the enclave, where Israel had said its forces completed operations months ago, residents said tanks had pushed back into Gaza City's Zeitoun suburb and were pounding several areas there.

Since early May, fighting has focused on Rafah, on Gaza's southern edge where around half of the enclave's 2.3 million people had been sheltering after fleeing other areas.

(Reuters)