Lebanese group Hezbollah said an Israeli strike killed two affiliated medics in southern Lebanon on Thursday in what it called a "blatant attack" on the first aid clinic where they worked.
"The Israeli enemy recently targeted a civil defence centre affiliated with the Islamic Health Committee in the town of Hanin, killing two martyrs," the group said in a statement.
"What happened is a blatant attack on a centre serving Lebanese citizens, providing relief and treating those wounded and injured in the ongoing Israeli aggression."
The Hezbollah-affiliated Islamic Health Committee said two of its staff had been killed by Israeli fire.
Hezbollah said it had launched "dozens of rockets" on the Israeli border town of Kiryat Shmona "in response".
Lebanon's health ministry condemned the attack "in the strongest terms" saying that it "directly targeted the Islamic Health Committee centre" and also hit an ambulance.
The Israeli army said that it had struck Hezbollah targets, including "military sites, a military post and terrorist infrastructure", as well "a number of areas in Lebanese territory".
On November 5, four first responders were wounded when an Israeli strike hit two ambulances in south Lebanon.
Hezbollah and Israel have exchanged near-daily cross-border fire since Israel's war on Gaza began on 7 October.
More than three months of violence have killed 190 people in Lebanon, including 25 civilians that have been killed in Israeli shelling on southern Lebanon, which also consist of children and journalists.
At least 140 Hezbollah fighters have also been killed there, and nine troops on the Israeli side of the border.
In northern Israel, nine soldiers and at least four civilians have been killed, according to Israeli authorities.
Hezbollah also launched rockets across the border at Israel on Thursday, as US special envoy Amos Hochstein met with Lebanese officials in Beirut in an attempt to cool tensions on the disputed frontier between Lebanon and Israel.