The United States vetoed a UN Security Council resolution on Wednesday calling for a "humanitarian pause" in the Israel's raging war on Gaza as the text "did not respect Israel's right to defend itself", the US ambassador said.
Twelve out of 15 Council members voted in favour of the resolution put forward by Brazil and negotiated over several days, while Russia and the United Kingdom abstained.
The United States was the only vote against it, but as one of the body's five permanent members, its vote counts as a veto.
"The United States is disappointed this resolution made no mention of Israel's rights of self-defence," US Ambassador to the UN Linda Thomas-Greenfield said after the vote.
The resolution said the Council "firmly condemns all violence and hostilities against civilians and all acts of terrorism."
It said the body "unequivocally rejects and condemns the heinous terrorist attacks by Hamas and the taking of hostages."
The text also "urges all parties to fully comply with their obligations under international law."
The vote comes after the Security Council on Monday rejected a Russian resolution condemning spiralling violence in the Middle East.
That resolution did not single out Hamas for its surprise attack on Israel on October 7, and it was rejected by permanent members of the United States, the United Kingdom and France, as well as Japan.
Israel has carried out its fiercest strikes on the blockaded Gaza enclave in 70 years, killing 3,478 Palestinians, according to health officials.
Tel Aviv has bombed residential buildings, hospitals and other key infrastructure while imposing a complete siege of Gaza, cutting off water, fuel and food in the densely-populated enclave home to 2.3 million people.