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The British scientists behind one of the major therapeutic trials have turned their focus to treatments for , a viral disease that has been labeled a global health emergency by the (WHO).

The team from theÌýUniversity of Oxford behind the so-called RECOVERY trial - which honed in on four effective CovidÌýtreatments –Ìýon Tuesday unveiled a new trial, dubbed PLATINUM, to confirm whether SIGA Technologies' tecovirimat is an effective treatment for monkeypox.

Although there are vaccines developed for the closely related smallpox that can reduce the risk of catching monkeypox, there are currently no treatments that have been proven to help hasten recovery in those who develop the disease.

More than 40,000 confirmed cases of monkeypox –Ìýincluding a handful of deaths –Ìýin over 80 countries where the virus is not endemic have been reported since early May.

Over 35 percent of the current global case count is in the United States, while the UK has over 3,000 confirmed cases.

The virus is transmitted chiefly through close contact with an infected person.

It typically causes mild symptoms including fever, rash, swollen lymph nodes and pus-filled skin lesions.

Severe cases can occur, though people tend to recover within two to four weeks, according to the WHO.

Siga's drug, branded Tpoxx, has been cleared to treat diseases caused by the family of orthopoxvirus that includes smallpox, monkeypox and cowpox by the European Union and United Kingdom, but due to limited trial data it is generally only used in severe cases in Britain.

In the United States and Canada, the drug is only approved to treat smallpox.

Since smallpox has been eradicated, and cases of monkeypox and cowpox typically occur sporadically, studies to assess the effectiveness of the drug in infected people have so far not been carried out.

Instead, its effectiveness is based on studies in animals infected with lethal doses of orthopoxviruses, as well tests of the medicine's effects in healthy humans.

The PLATINUM trial, funded by a £3.7 million ($4.35 million) UK government grant, aims to recruit at least 500 participants.

Participants will either be given a 14-day course of tecovirimat twice daily, or a placebo.

The United States will boost its supply of monkeypox vaccine by making an additional 1.8 million doses of Bavarian Nordic's Jynneos vaccine.

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To assess the drug's effectiveness, the rate at which lesions heal, the time taken until patients test negative for the virus, and the proportion of patients who require hospitalisation due to complications will be tracked.

"I'm hoping that we can have a result before Christmas, but it depends on the rate of recruitment," said Sir Peter Horby, Professor of Emerging Infections and Global Health at the University of Oxford and the director of the new Pandemic Sciences Institute.

Earlier this month, Ìýofficials indicated they were planning a randomised clinical trial in the country to determine whether tecovirimat should secure AmericanÌýapproval for monkeypox.

Siga, which sells an oral and intravenous formulation of the drug, has already received $60 million worth of orders for oral tecovirimat this year.

Meanwhile, the only approved monkeypox vaccine –Ìýmade by Danish company Bavarian Nordic –Ìýis in short supply, pushing countries to stretch existing supplies.

(Reuters)